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	Provedor de dados BJMBR (1) Autor Branco,L.G.S. (1) Nascimento,C.G.O. (1) Palavra-chave Antinociception (1) Carbon monoxide (1) Formalin (1) Hypernociception (1) Nociception (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2009 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Antinociception synergy between the peripheral and spinal sites of the heme oxygenase-carbon monoxide pathway BJMBR Nascimento,C.G.O.; Branco,L.G.S.. We have shown that the peripheral and spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase-cGMP pathways play an important role in antinociception in the rat experimental formalin model. Our objective was to determine if there is synergism between peripheral (paw) and spinal HO-CO pathways in nociception. Rats were handled and adapted to the experimental environment for a few days before the formalin test, in which 50 µL of a 1% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The animals were then observed for 1 h and the frequency of flinching behavior was taken to represent the nociceptive response. Thirty minutes before the test, rats were pretreated with intrathecal injections of the HO... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nociception; Carbon monoxide; Formalin; Hypernociception; Antinociception. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100020 Registros recuperados: 1 Primeira ... 1 ... Última

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